| Objective This study aimed to analyze and summarize the clinical features of Listeria monocytogenes (LM) sepsis in both non-pregnant and pregnant patients for improved clinical diagnosis and treatment strategies. Methods?A retrospective investigation was conducted on 12 non-pregnant patients and 12 pregnant patients diagnosed with LM sepsis by blood cultures between October 2010 and June 2021 at Beijing Chaoyang Hospital. Results?The study revealed common clinical manifestations such as fever and gastrointestinal symptoms. Notably, fetal heart abnormalities were observed in 33% (n=4) of pregnanct cases, while 41.7% (n=5) non-pregnant women with LM sepsis experienced central nervous system.The analysis indicated significant differences in white blood cell counts (×109/L) (15.44±6.59 vs. 7.58±3.89, P=0.002), neutrophil counts (×109/L) (11.94±6.17 vs. 6.45±3.65, P=0.015), and lymphocyte counts (×109/L) (2.32±1.39 vs. 0.66±0.55, P=0.001) between pregnant and non-pregnant patients. Moreover, C-reactive protein levels (mg/L) were higher in non-pregnant patients [13.35 (35.28) vs 42.5 (161.23), P=0.011]. Initial empirical treatments in both groups mainly involved cephalosporins. Adjusted treatment after LM diagnosis by blood cultures resulted in 5 deaths among non-pregnant patients, whereas there were no deaths in the pregnant group, with 2 successful smooth deliveries, One newborn was diagnosed with early-onset Listeria septicemia, recovering after treatment with penicillin sodium and Meropenem. Conclusions?This study indicated the importance of timely and accurate treatment of LM infection, particularly during early pregnancy, to mitigate adverse pregnancy outcomes. Clinically, the use of antibacterial drugs targeting listeria monocytogenes and prompt etiological clarification can significantly improve patient prognosis during fever or suspected sepsis, regardless of immune status. |