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| 鲍曼不动杆菌双组份调控系统研究进展 |
| Research progress onthe two-component regulatory systems of Acinetobacter baumannii |
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| DOI：10.3969/j.issn.1007-8134.2022.05.015 |
| 中文关键词: 鲍曼不动杆菌 双组份调控系统 耐药性 |
| 英文关键词: Acinetobacter baumannii two component regulatory system drug resistance |
| 基金项目:山西省应用基础研究计划（20210302123279） |
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| 中文摘要: |
| [摘要]?鲍曼不动杆菌是一种需氧非发酵乳糖的革兰阴性杆菌，为医院环境中广泛存在的条件致病菌之一，可导致医院获得性感染，其粘附力强、抵抗力强、适应环境能力强、耐药率高等特点使它成为威胁人类健康最重要的病原体之一。多重耐药鲍曼不动杆菌、泛耐药鲍曼不动杆菌、全耐药鲍曼不动杆菌的出现为临床治疗带来巨大挑战。双组份调控系统（two component regulatory systems, TCSs）在鲍曼不动杆菌的环境感知和适应中发挥着关键作用，使其在不断变化的环境中广泛存在且长期存活。因此，TCSs小分子抑制剂或可成为抗微生物感染的新靶点。 |
| 英文摘要: |
| [Abstract]?Acinetobacter baumannii is an aerobic non-fermenting lactose Gram-negative coccobacillus and is one of the mosta widespread conditional pathogens in the hospital environment, causing hospital-acquired infections, its strong adhesion and high drug resistance make this pathogen one of the most important threats to human health. The emergence of multi-drug resistant, pan-drug resistant and fully drug resistant Acinetobacter baumannii poses a major challenge for clinical treatment. The two-component regulatory systems (TCSs) plays a key role in the environmental awareness and adaptation of Acinetobacter baumannii, enabling its widespread presence and long-term survival in a changing environment. Therefore, small molecule inhibitors of TCSs may become new targets in microbial infectionstreatment. |
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