| [Abstract] Objective This study aimed to study the epidemiological characteristics, clinical characteristics, serology and genotype of scrub typhus in Xiangyun Country, Yunnan Province. Methods?In this study enrolled 1033 scrub typhus patients reported online by the Chinese Center for Disease Control and Prevention from January 2020 to December 2021 to study the distribution characteristics of scrub typhus epidemiology, clinical symptoms, laboratory data, serological and genetic test results in Xiangyun Country, Yunnan Province. Results?The prevalence of scrub typhus in Xiangyun Country, Yunnan Province was mostly men, aged between 41 and 60 years, farmers, and the incidence was higher in summer. The main clinical symptoms of the patients were high fever, skin ulcers or eschar, and chills. Laboratory tests showed that 61.28%patients had eosinophils＜ 0.5×109/L, 55.57% patients had hemoglobin ＜ 120 g/L, 63.41%patients had C-reactive protein＞ 8 mg/L, and 50.73% patients had ALT＞ 50 U/L. Serology was dominated by Kato and genotypes were dominated by groEL. GroEL genotypes of scrub typhuswere in the same branch as AH-GD-OT-S6(GQ499933), UT332(EF551306), Kato(AY191586), Karp(M31887), and ZJ-TT-OT-O21(GQ499953) strains from clinicalreports. Conclusions?Xiangyun County of Yunnan Province has become one of the most important endemic areas of Scrub typhus. It is of great significance for the prevention and control of scrub typhus to detect the serotype and genotype of the disease. |