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| 表观扩散系数值与肝细胞癌分级的相关性以及相关性与肿瘤大小关系的分析 |
| Analysis of the correlation between the value of apparent diffusion coefficient and the grade of hepatocellularcarcinoma and the relationship between the correlation and tumor size |
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| DOI：10.3969/j.issn.1007-8134.2022.06.010 |
| 中文关键词: 表观扩散系数 肝细胞癌 肿瘤大小 肿瘤组织学分级 相关性分析 ROC曲线 灵敏度 特异度 |
| 英文关键词: apparent diffusion coefficient hepatocellular carcinoma tumor size tumor histological grading correlation analysis ROC curve sensitivity specificity |
| 基金项目:沧州市科技计划自筹经费项目（204106080) |
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| 中文摘要: |
| [摘要] 目的 探讨表观扩散系数（apparent diffusion coefficient, ADC）值与肝细胞癌（hepatocellular carcinoma, HCC）组织学分级的相关性以及不同直径肿瘤的ADC值与HCC的相关性。方法?回顾性分析2017年—2020年180例病理证实为HCC的病例资料，按肿瘤直径大小分为＜2 cm、≥2 cm且＜3 cm、≥3 cm且＜5 cm、≥5 cm 4组，标为I、II、III、IV组。分析ADC值与HCC组织学分级的相关性，并分析在不同直径肿瘤ADC值与HCC的相关性。结果?高、中和低分化HCC的ADC值分别为（1.159±0.302）×10-3、（0.951±0.213）×10-3和（0.811±0.239）×10-3 mm2/s，逐级降低（P＜0.05）。ADC值与总体HCC的组织学分级呈负相关（r=-0.474），与I～III组HCC的组织学分级均呈负相关（r值分别为-0.663、-0.527、-0.364），而与IV组HCC的组织学分级无相关性。结论?ADC值可以作为非侵入性预测HCC组织学分级的指标，预测结果受肿瘤大小影响，更适用于小肝细胞癌。 |
| 英文摘要: |
| [Abstract] Objective To investigate the correlation between apparent diffusion coefficient (ADC) value and hepatocellular carcinoma (HCC) grade and the correlation between ADC value and HCC in different tumor diameters. Methods?A retrospective analysis of 180 cases with pathologically confirmed HCC from 2017 to 2020 were divided into four groups according to size:＜2 cm,≥2 cm and＜3 cm,≥3 cm and＜5 cm,≥5 cm, labeled as group I, II, III, and IV, respectively. Analyze the correlation between ADC value and HCC histological grade, and analyze the difference between theADC value and HCC in different tumor diameters. Results?The ADC values of well, moderatlye and poorly differentiated HCC were (1.159±0.302)×10-3, (0.951±0.213)×10-3 and (0.811±0.239)×10-3 mm2/s respectively (P＜0.05). The ADC value was negatively correlated with the histological grade of HCC in general (r=-0.474), and negatively correlated with the histological grade of HCC in groups I-III, respectively (r=-0.663, -0.527, -0.364). There was no significant correlation between HCC grade and histological grade in Group IV. Conclusions?ADC value may be a useful tool for non-invasively predicting HCC histological grade. The predictive value is affected by tumor size. It may be more suitable for small HCC. |
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