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| 新型冠状病毒关切变异株的研究进展 |
| Expert consensus on diagnosis and treatment Research progress on SARS-CoV-2 variants of concern |
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| DOI：10.3969/j.issn.1007-8134.2022.06.001 |
| 中文关键词: 新型冠状病毒 新型冠状病毒肺炎 公共卫生事件 关切变异株 免疫逃逸 疫情防控 研究进展 |
| 英文关键词: SARS-CoV-2 COVID-19 public health emergency variants of concern immune escape epidemic prevention and control research progress |
| 基金项目:陕西省2020年重点研发计划（2020ZDXM-SF006） |
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| 中文摘要: |
| [摘要]?新型冠状病毒（severe acute respiratory syndrome coronavirus 2, SARS-CoV-2）属于β属冠状病毒，是一类具有囊膜的线性单股正链RNA病毒，可引起人类罹患新型冠状病毒肺炎（coronavirus disease 2019, COVID-19）。自2019年12月被发现以来，SARS-CoV-2迅速在全球流行蔓延，已导致近650万人死亡，给各国医疗卫生体系带来沉重负担，成为自二战以来最严重的全球性突发公共卫生事件。SARS-CoV-2在广泛复制的过程中不断发生变异，产生新的变异株。截至目前，WHO共定义了5种关切变异株（variants of concern, VOC），分别为Alpha、Beta、Gamma、Delta和Omicron。SARS-CoV-2 VOC在传染性、致病性、中和抗体敏感性和免疫逃逸等方面均有可能增强。本文从冠状病毒概况、SARS-CoV-2 VOC的分类以及VOC对COVID-19诊治的影响等几个方面进行了综述，为更精准疫情防控提供科学依据，为后续研究提供科学参考。 |
| 英文摘要: |
| [Abstract]? Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a kind of RNA virus with capsule membrane and linear single positive strand genome, belongs to the β genus of coronavirus. This virus can cause coronavirus disease 2019 (COVID-19). Since it was discovered in December 2019, SARS-CoV-2 had rapidly spread around the world, and result nearly 6.5 million deaths. It has placed heavy burden on the health care of all countries and become the most serious global public health emergency since World War II. SARS-CoV-2 continues to mutate as it replicates widely and new variants emerge. As so far, WHO has defined 5 SARS-CoV-2 variants of concern (VOC), Alpha, Beta, Gamma, Delta and Omicron. SARS-CoV-2 VOC may exhibit enhanced abilities of infectious sensitivity, pathogenicity, neutralizing antibodies and immune escape. In this review, we described the research progress on SARS-CoV-2 VOC from the coronavirus overview, VOC classifications, and the influence of VOC on COVID-19 diagnosis and treatment, which could provide scientific basis for more accurate and scientific prevention and control of epidemic and scientific reference for subsequent researches. |
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