| [Abstract] Objective The present study aimed to investigate the incidence of adverse drug reaction (ADR) patients with AIDS and fungal infections who treated with amphotericin B (AmB). Methods The Cox model was used to evaluate the incidence of ADR and intervention resultsof 1739 patients who were conformed at The Fourth People's Hospital of Nanning, from October 1, 2017, to June 30, 2021. Results The incidence rate of ADR in patientswith AIDS and fungal infections , who were treated with AmB, was 6.96%（121/1739) and the rate of severe ADR was 2.01% (35/1739). The ADR incidence rate of male (7.91%)was significantly higher than that of female (3.49%) (P＜0.05). More than 66.88% patients suffered from renal dysfunction, hypokalemia, and liver dysfunction. Severe ADR occurred in 2 to 22 days after medication, and most of those occurred within 10 days. Different interventions were performed according to the severity of ADR, including continued initial AmB treatment, reduced dosage and discontinued treatment. The effective rate of timely intervention was up to 85.95%. Conclusions There are various ADR in patients with AIDS and fungal infections, who are treated with domestic AmB, among which renal dysfunction, hypokalemia, and liver dysfunction occurred frequently. The incidence rate of male is higher than that of female. However, the effective rate of intervention will be proved if ADR are well monitored. After all, treating with domestic AmB is generally safe in patients with AIDS and fungal infections. |