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| 147例梅毒合并丙型肝炎患者病原学检测及流行病学分析 |
| Etiological detection and epidemiological analysis of 147 syphilis patients with hepatitis C |
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| DOI：10.3969/j.issn.1007-8134.2021.03.014 |
| 中文关键词: 梅毒 丙型肝炎 病原学 流行病学 发病年龄 传播途径 高危人群 传染性疾病 |
| 英文关键词: syphilis hepatitis C etiology epidemiology age of onset route of transmission high-risk population infectious disease |
| 基金项目:海南省卫生健康委员会普通科研课题（16A200118） |
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| 中文摘要: |
| 目的 探究147例梅毒合并丙型肝炎（丙肝）患者病原学检测情况及流行病学特征，以期为传染病防治提供一定参考依据。方法 选取2018年1月—2020年12月我院收治的752例梅毒患者作为研究对象，根据是否合并丙肝将其分为单纯梅毒组（n=605）和梅毒合并丙肝组（n=147），并对其进行病原学检测和流行病学调查，分析患者病原体感染情况及流行病学特征。结果 2组均以男性患者为主，年龄以18～40岁居多，职业中以农民、工人占比较高。2组梅毒病情分期差异有统计学意义，梅毒合并丙肝组病情更严重（P＜0.05）；梅毒合并丙肝组输血传播途径比例（63.95%）高于单纯梅毒组（31.74%），性传播途径比例（21.77%）低于单纯梅毒组（30.41%）（P均＜0.05）。752例梅毒患者中，合并丙肝患者共147例，占20.08%，且梅毒合并丙肝患者占梅毒患者比例呈逐年升高趋势（P＜0.05）。此外，147例梅毒合并丙肝患者中，39例合并其他传染性疾病，占26.53%。结论 梅毒合并丙肝患者发病率有逐年升高趋势，且病情较单纯梅毒患者更为严重，临床工作中应针对高危人群做好疾病预防与干预工作。 |
| 英文摘要: |
| Objective To explore the etiological detection and epidemiological characteristics of 147 syphilis patients with hepatitis C so as to provide certain reference basis for the prevention and control of infectious diseases. Methods Seven hundreds and fifty-two patients with syphilis who were admitted to our hospital from January 2018 to December 2020 were selected. According to the absence or presence of hepatitis C, the patients were divided into simple syphilis group (n=605) and syphilis with hepatitis C group (n=147) and subjected to the etiological detection and epidemiological investigation. The pathogenic infection and epidemiological characteristics of patients were analyzed. Results In 2 groups, male patients were predominant, the age peaked at 18-40 years, the farmers and workers accounted for a high proportion of occupation. There was a statistically significant difference in the stages of syphilis between 2 groups, and the disease condition in the syphilis with hepatitis C group was more severe (P＜0.05). The proportion of blood transfusion transmission in the syphilis with hepatitis C group (63.95%) was higher than that in the simple syphilis group (31.74%), and the proportion of sexual transmission in the syphilis with hepatitis C group (21.77%) was lower than that in the simple syphilis group (30.41%) (P＜0.05). Among 752 patients with syphilis, 147 cases had HCV infection, accounting for 20.08%, and the proportion of syphilis with hepatitis C patients in syphilis patients increased year by year (P＜0.05). In addition, among 147 syphilis patients with hepatitis C, 39 cases had other infection diseases, accounting for 26.53%. Conclusions The prevalence of syphilis patients with hepatitis C tends to increase year by year. The syphilis with hepatitis C condition is more severe than syphilis alone. In clinical work, disease prevention and intervention should be targeted at high-risk population. |
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