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| 2012—2017年潍坊市艾滋病抗病毒治疗失败影响因素分析 |
| Analysis on influencing factors of antiviral therapy failure for HIV in Weifang City from 2012 to 2017 |
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| DOI：10.3969/j.issn.1007-8134.2021.03.013 |
| 中文关键词: 潍坊市 艾滋病 流行病学 抗病毒疗效 影响因素 干预措施 |
| 英文关键词: Weifang City HIV/AIDS epidemiology antiviral efficacy influencing factor intervention |
| 基金项目:山东省医药卫生科技发展计划项目（2017WS778）；潍坊市卫生计生委科研项目（wfwsjs_2018_001） |
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| 中文摘要: |
| 目的 探讨2012—2017年潍坊市艾滋病流行病学特点及抗病毒治疗失败的影响因素。方法 选择2012年1月—2017年12月潍坊市艾滋病注册患者299例作为研究对象，分析艾滋病的流行病学特点；对艾滋病患者均给予常规抗病毒治疗，12个月治疗后评估疗效，并根据疗效分为成功组和失败组。查阅2组病历资料，对抗病毒治疗失败可能的影响因素进行单因素及多因素Logistic分析。结果 2012—2017年潍坊市艾滋病发病例数呈逐年上升趋势，2017年达到90例；299例患者年龄24～51岁，平均（41.59±5.71）岁；感染时间1～15年，平均（8.41±0.69）年；发病人群以男性为主（94.98%），发病年龄＜50岁患者占89.97%；56.52%患者为未婚/离异；文化程度以高中及以下为主，占62.21%；传播途径以性传播为主；47例治疗失败，失败率为15.72%。多因素Logistic分析结果表明：年龄≥50岁、病程＞8年、基线CD4+ T淋巴细胞计数＜500个/μl、合并感染及存在药物不良反应是潍坊市艾滋病患者抗病毒治疗失败的不利影响因素（P均＜0.05）。结论 2012—2017年潍坊市艾滋病发病例数呈逐年上升趋势，且男男性行为者是艾滋病流行高危人群；抗病毒治疗虽然能获得良好效果，但影响因素较多，应采取相应的干预措施，提高抗病毒疗效。 |
| 英文摘要: |
| Objective To explore the prevalence of AIDS epidemic and the influencing factors of antiviral therapy failure in Weifang City from 2012 to 2017. Methods A total of 299 registered AIDS patients in Weifang City from January 2012 to December 2017 were selected to analyze the epidemiological characteristics of AIDS. All patients were treated with conventional antiviral therapy, and the efficacy was evaluated after 12 months of treatment. According to the therapy efficacy, patients were divided into success group and failure group. According to the medical records of 2 groups, the possible influencing factors of antiviral therapy failure were analyzed by univariate and multivariate Logistic analysis. Results The number of AIDS cases in Weifang City increased year by year from 2012 to 2017 and reached 90 in 2017. The age of 299 patients was 24-51 years old, with an average of (41.59±5.71) years old. The time of infection was 1-15 years, with an average of (8.41±0.69) years. The majority of the patients were male (94.98%), and the age of onset was less than 50 years old in 89.97% and 56.52% of the patients were unmarried/divorced. The education level was mainly below high school, accounting for 62.21%. Sexual transmission was the main routes of transmission. The therapy failed in 47 cases, and the failure rate was 15.72%. Multivariate Logistic analysis showed that the age ≥50 years, course of disease＞8 years, baseline CD4+ T lymphocytes ＜500 cells/μl, co-infection and drug side effects were the adverse influencing factors for the failure of antiviral therapy for AIDS patients in Weifang City (P＜0.05). Conclusions The number of AIDS cases in Weifang City increases year by year from 2012 to 2017. MSM was a high-risk group of AIDS epidemic. Although antiviral therapy can achieve good results, there are many factors affecting the efficacy failure. Therefore, corresponding intervention measures should be taken to improve the antiviral effect. |
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