| Objective To investigate the clinical features of adult patients with liver injury related to EBV infection, and improve the clinician’s understanding of EBV infection with liver injury in adults. Methods Fourteen adult patients with liver injury related to EBV infection who were admitted to Beijing Youan Hospital, Capital Medical University from September 2015 to September 2020 were included in this study. Their clinical features were analyzed retrospectively. The literatures also were reviewed based on the research progress of this disease. Results The main clinical manifestations of 14 patients included fever, pharyngitis and lymphadenectasis, accounting for 92.8%, 78.6%, and 35.7% respectively. Other symptoms included chills (35.7%), nausea (28.6%), vomiting (21.4%), shivering (14.3%), yellow urine and yellowing of the skin (14.3%). Laboratory tests mainly showed the elevation of peripheral lymphocyte count, abnormal lymphocyte ratio, ALT, and AST (100%), with normal PTA and INR (100%). Other manifestations included the elevation of ALP and GGT with normal or elevated TBIL (42.8%) and DBIL (35.7%). The manifestation of abdominal ultrasound was splenomegaly in predominant cases (85.7%) and hepatosplenomegaly in rare case (7.1%). All 14 patients (100%) received liver-protection symptomatic treatment, including 5 cases (35.7%) combined with ganciclovir, 1 case (7.1%) combined with acyclovir, and 1 case (7.1%) combined with short-acting recombinant human interferon α-1b. All 14 patients (100%) improved and were discharged from the hospital. Conclusions The main clinical manifestations of adult patients with liver injury related to EBV include fever, pharyngitis, and lymphadenectasis. Laboratory tests mainly include the elevation of aminotransferase, often accompanied by splenomegaly. At present, a symptomatic supportive treatment is recommended and the overall prognosis is good. |