Objective To retrospectively analyze the white blood cell scatter diagrams, peripheral blood smear characteristics and other laboratory indicators of 27 AIDS patients with disseminated Talaromyces marneffei (TM) infection, and find the indicators for early identification of AIDS combined with talaromycosis marneffei (TSM). Methods Twenty-seven AIDS patients combined with TSM diagnosed by peripheral blood smear were taken as the AIDS combined with TSM group. Meanwhile, 2 control groups were set, including simple HIV infected patients and AIDS patients complicated with other diseases. The characteristics of white blood cell scatter diagrams, manual classification and count of white blood cells, and morphological characteristics of peripheral blood cells in the three groups were analyzed. The routine blood test, CD4+ T lymphocyte count, transaminase and (1, 3)-β-D-glucan (BDG) results were compared. Results The white blood cell scatter diagrams of the AIDS combined with TSM group all showed scattered dots in the nucleated red blood cells area, and peripheral blood smears showed nucleated red blood cells. At the same time, immature and deformed granulocytes were visible. The white blood cell scatter diagrams and blood smear morphology of the simple HIV infection group were not abnormal. In the scatter diagrams of the AIDS with other complications group, some granulocytes were scattered upward, and the blood smear showed immature and deformed granulocytes. The overall differences in leukocyte classification were statistically significant among 3 groups (P<0.05). Comparison of white blood cells, red blood cells, hemoglobin, platelet, AST, ALT, BDG, CD4+ T lymphocyte count levels among 3 groups showed statistical significance (P<0.05). Conclusions The white blood cell scatter diagrams and peripheral blood morphology of AIDS combined with TSM group show abnormal manifestations with the specific indication of the emerging nucleated red blood cells. The neutrophil ratio, AST and BDG levels increase, CD4+ T lymphocyte count and platelet decrease significantly. |