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| 对一起汉滩病毒感染案例44年后长时效体液免疫应答的回顾性分析 |
| Retrospective analysis of long-term immunity protection in a case of hantaan virus infection after 44 years |
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| DOI：10.3969/j.issn.1007-8134.2020.04.008 |
| 中文关键词: 汉滩病毒 实验室感染 免疫保护 中和抗体 |
| 英文关键词: HTNV laboratory infection immune protection neutralization antibody |
| 基金项目:陕西省自然科学基础研究计划（2018JQ8060）；国家自然科学基金（81701555） |
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| 中文摘要: |
| 目的 探讨汉滩病毒（hantaan virus, HTNV）感染者长时效体液免疫应答情况，为研究长时效体液免疫应答规律提供参考依据。方法 采集4名 HTNV感染者感染44年后的血清，通过酶联免疫吸附试验和HTNV中和抗体检测技术检测分析患者血清中HTNV特异性抗体IgM、IgG及中和活性抗体滴度。结果 4名HTNV感染者血清中均检测到不同滴度的HTNV特异性IgG抗体，其滴度最高可达1∶800，HTNV特异性IgM抗体均未检测到。此外，在血清中也检测到不同滴度的中和活性抗体，其滴度最高可达1∶10。结论 HTNV感染44年后体内仍存在长时效体液免疫应答，其可以为感染者提供终身免疫保护。 |
| 英文摘要: |
| Objective To investigate the long-term humoral immune response in patients infected with hantaan virus (HTNV) and provide references for the study of long-term humoral immune response. Methods The sera from 4 patients infected with HTNV were collected after 44 years. The titers of HTNV-specific antibodies IgM and IgG as well as the neutralization antibody in their sera were analyzed by using enzyme linked immunosorbent assay and neutralization antibody test. Results Among the 4 HTNV-infected patients, the presence of different titers of HTNV-specific IgG antibodies were detected in the sera, and the titer was up to 1∶800. But the HTNV-specific IgM antibodies were not detected. In addition, different titers of neutralization antibodies were also detected in their sera, the titer was up to 1∶10. Conclusions There is a long-lasting humoral immune response in the body after 44 years of HTNV infection, and it provides a lifelong immune protection for the infected patients. |
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