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| 帕拉米韦氯化钠注射液治疗儿童流行性感冒的效果及安全性 |
| Efficacy and safety of peramivir and sodium chloride injection in treatment of influenza in children |
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| DOI：10.3969/j.issn.1007-8134.2020.03.009 |
| 中文关键词: 帕拉米韦 奥司他韦 儿童 流行性感冒 |
| 英文关键词: peramivir oseltamivir children influenza |
| 基金项目:保定市科学计划与发展指导计划项目（17ZF062） |
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| 中文摘要: |
| 目的 探讨帕拉米韦氯化钠注射液治疗儿童流行性感冒（流感）的效果及安全性，为临床安全用药提供依据。方法 选取2017年1月—2018年12月涿州市医院收治的流感患儿260例，按照随机数字表法将其分为观察组（n=130）和对照组（n=130）。对照组给予磷酸奥司他韦颗粒治疗，观察组给予帕拉米韦氯化钠注射液治疗，观察2组的疗效及安全性。结果 观察组治疗后的体温恢复正常时间、咳嗽缓解时间、鼻卡他/鼻塞缓解时间、咽喉痛缓解时间及症状完全缓解时间均明显低于对照组，差异有统计学意义（P均＜0.05）。观察组治疗后的总有效率明显高于对照组（96.2% vs. 83.8%，P＜0.05）。观察组治疗前后血常规各项指标与对照组比较，差异均无统计学意义（P均＞0.05）。观察组与对照组治疗后不良反应发生率比较，差异无统计学意义（8.5% vs. 12.3%，P＞0.05）。结论 采用帕拉米韦氯化钠治疗儿童流感的效果较好，能更快地改善流感症状，且不会增加不良反应。 |
| 英文摘要: |
| Objective To explore the efficacy and safety of peramivir and sodium chloride injection in treatment of influenza in children and provide evidence for clinical safe drug use. Methods Totally 260 children with influenza admitted to Zhuozhou City Hospital from January 2017 to December 2018 were selected, and they were divided into observation group (n=130) and control group (n=130) according to random number table method. The control group was treated with oseltamivir phosphate granules, while the observation group was treated with peramivir and sodium chloride injection. The efficacy and safety of 2 groups were observed. Results The time of normal temperature recovery, cough relief, nasal catarrh/nasal congestion relief, throat pain relief and complete symptom relief in the observation group after treatment were significantly lower than those in the control group, with statistically significant differences (P＜0.05). The overall effective rate of the observation group after treatment was significantly higher than that of the control group (96.2% vs. 83.8%, P＜0.05). Before and after treatment, various indexes of blood routine test showed no statistically significant difference between the observation group and the control group (P＞0.05). There was no statistically significant difference in the incidence of adverse reactions after treatment between the observation group and the control group (8.5% vs. 12.3%, P＞0.05). Conclusions Peramivir and sodium chloride injection is an effective treatment for childhood influenza. It can improve flu symptoms quickly without increasing adverse reactions. |
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