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| 儿童接种乙肝疫苗后乙肝表面抗体滴度的影响因素分析 |
| Analysis of factors influencing the titer of hepatitis B surface antibody in children inoculated with hepatitis B vaccine |
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| DOI：10.3969/j.issn.1007-8134.2019.06.013 |
| 中文关键词: 乙肝疫苗 预防接种 低免疫反应 |
| 英文关键词: hepatitis B vaccine vaccination low immune response |
| 基金项目: |
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| 中文摘要: |
| 目的 分析乙型肝炎（乙肝）表面抗体阴性的儿童加强免疫后抗体滴度的影响因素。方法 选取2017年1—12月期间海南省妇幼保健院乙肝疫苗免疫后乙肝表面抗体阴性的84名儿童作为研究对象，比较1～3岁及4～7岁儿童的抗体滴度，并分析低免疫或无免疫反应的相关因素。结果 1～3岁儿童抗体滴度显著高于4～7岁儿童（P＜0.05）。30例（35.71%）儿童接种乙肝疫苗后呈低免疫反应，无患儿出现无免疫反应。Logistic多因素分析显示：年龄≥4岁是接种疫苗后低免疫反应的危险因素，母乳喂养时间越长、体质量百分位数越大、血清总蛋白越高，低免疫反应发生率越低。结论 年龄是儿童乙肝疫苗接种后抗体滴度的主要影响因素，母乳喂养及营养状态亦对免疫反应产生影响。 |
| 英文摘要: |
| Objective To analyze the influencing factors of antibody titer in children with negative hepatitis B surface antibody after booster immunization. Methods From January 2017 to December 2017, 84 children who were negative for hepatitis B surface antibody after booster immunization with hepatitis B vaccine in Hainan Maternal and Child Health Hospital were selected as the study objects. The antibody titers of children aged 1-3 years and 4-7 years were compared and the related factors of low immunity or no immune response were analyzed. Results The antibody titer of children aged 1-3 years was significantly higher than that of children aged 4-7 years (P＜0.05). Thirty (35.71%) children showed low immune response after hepatitis B vaccination and no child showed no immune response. Logistic multivariate analysis showed that age≥ 4 years was the risk factor of low immune response after vaccination. The longer period of breast-feeding, the higher weight percentage, and the higher total protein in blood were associated with the lower incidence of low immune response. Conclusions The age is the major factor affecting the antibody titer of children after hepatitis B vaccination. Breastfeeding and nutritional status also affect the immune response. |
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