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| 哈尔滨市108例新发HIV-1感染者体内CRF01-AE亚型毒株成簇性分析 |
| Cluster analysis of CRF01-AE subtype recombinant strains in 108 newly diagnosed HIV-1 infected cases in Harbin |
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| DOI：10.3969/j.issn.1007-8134.2019.06.006 |
| 中文关键词: 男男性行为 CRF01-AE 传播簇 HIV-1感染 |
| 英文关键词: men who have sex with men CRF01-AE transmission cluster HIV-1 infection |
| 基金项目:“十三五”国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（2018ZX10302104-001-005）；国家自然科学基金面上项目（81672003） |
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| 中文摘要: |
| 目的 了解哈尔滨市男男性行为（men who have sex with men, MSM）人群中新确诊HIV-1感染者体内CRF01-AE亚型毒株成簇性特征，为制定科学有效的防控措施提供依据。方法 收集哈尔滨市2017年新确诊MSM人群中HIV-1感染者流行病学及人口学信息，通过DNA测序和基因分型，对CRF01-AE亚型的序列进行成簇性分析。结果 本研究共获得108条CRF01-AE亚型序列，以簇内基因距离≤0.045和Bootstrap≥90%为界定簇标准，产生传播簇15个，其中由10条序列构成的传播簇1个；患者年龄、常住地、性伴数、性取向、婚姻状况、性病史在未成簇与成簇2组中差异均具有统计学意义（P均＜0.05）。结论 CRF01-AE亚型毒株是哈尔滨市MSM HIV-1感染者中的优势传播株，具有较强的成簇性，在艾滋病防控中对于未婚、性行为活跃的青壮年人群及与该人群关系密切的人群须高度关注。 |
| 英文摘要: |
| Objective To provide the scientific evidence for effective prevention and controlling measures of AIDS by getting information of the cluster characteristics of CRF01-AE subtype recombinant strains in newly diagnosed HIV-1 infected men who have sex with men (MSM) in Harbin. Methods The epidemiological and demographic information of newly diagnosed HIV-1 infected MSM in Harbin in 2017 were collected. The CRF01-AE subtype sequence was analyzed in cluster by using DNA sequencing and genotyping technology. Results A total of 108 CRF01-AE subtype sequences were acquired. According to the criteria of defining a cluster with gene distance ≤0.045 and Bootstrap≥90%, 15 transmission clusters were obtained, of which only 1 cluster consisted of 10 sequences. The age, permanent residence, number of sexual partners, sexual orientation, marital status, history of venereal disease were statistically significant between non-clustering group and clustering group (P＜0.05). Conclusions CRF01-AE subtype recombinant strain is the dominant transmission strain among MSM infected by HIV-1 in Harbin, and it has strong clustering potential. In the prevention and control of AIDS, we should pay great attention to the unmarried, sexually active young and middle-aged people and the people closely related to the infected MSM. |
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